Vardenafil powder

Vardenafil raw powder CAS224785-90-4 GMP factory supply

1: What Is Vardenafil Powder & Specifications and Core Pharmaceutical Applications

1.1 What is Vardenafil Powder API

Vardenafil powder is a PDE5 inhibitor that takes effect in as little as 20 minutes, with virtually no eye side effects, perfect for people with diabetes. Other PDE5 inhibitor medicines include sildenafil citrate, sildenafil mesylate, tadalafil, avanafil powder, water-soluble tadalafil, alcohol-soluble tadalafil, tadalafil derivatives, undetected tadalafil analogs like Jinyangjian, Xinyangjian, Huanyangjian, 520, SX. Plant PDE inhibitors like epimedium extract, Ginseng extract, and Kaempferia parviflora.
Vardenafil powder can be combined with dapoxetine; it takes 20 minutes to make immediate-release tablets with dapoxetine HCL. Dapoxetine does not belong to PDE inhibitors; dapoxetine is the only oral medicine for premature ejaculation. It belongs to the class of SSRI inhibitors(Selective Serotonin Reuptake Inhibitors).

1.2 Vardenafil Powder API Chemical Specifications & CAS Number
1.2 .1 API name: Vardenafil Powder
1.2 .2 Appearance: White crystal powder
1.2 .3 Taste: Compared with sildenafil citrate, avanafil, and tadalafil, vardenafil has the strongest bitter taste.
1.2 .4 Specification: 98%-102% powder according to USP, EP
1.2 .5 CAS No.:224785-90-4
1.2 .6 Molecular Formula: C23H32N6O4S
1.2 .7 Molecular Weight: 488.6
1.2 .8 Certificates: GMP, cGMP, CEP, CDE, FDA, Organic, Kosher, ISO, HALAL, FSSC, DMF
1.2 .9 Testing partner of independent lab: Wuxi AppTec, Merieux
1.2 .10 Test Method: HPLC, UV-visible spectrophotometry
1.2 .11 Storage method:15～25℃, RH＜60%, store away from light
1.2 .12 Export only, welcome research labs and professionals

1.3 Pharmaceutical Applications (5 Benefits of Vardenafil powder for Health).
1.3.1 Works well for erection problems from diabetes.
1.3.2 Few side effects, hardly any eye issues.
1.3.3 Boosts blood vessel health all over the body.
1.3.4 Has little impact on heart rate and blood pressure, safer for the heart.
1.3.5 Takes effect gently, lasts properly, and eases mental pressure.

2: FAQ about Vardenafil powder

2.1 Vardenafil powder Order Quantity
10g: Free samples for your lab test and even body test
1kg: Trial order to test our secure door-to-door delivery service
25kg–200kg: Ideal for you to check our stable product supply; new batches are in stock
200kg–500kg: We will reship free of charge if goods get lost. We are your reliable partner
500kg and above: Each batch comes with an HPLC test report. We can meet your specific requirements on impurities and particle size, and we’ll be your ideal finished product partner.

2.2 Vardenafil powder packaging

10g: Packed in aluminum foil bags with inner transparent PE bags to prevent leakage
1kg: Packed in aluminum foil bags with inner transparent PE bags to prevent leakage
25kg–200kg: Blue tamper-proof HDPE plastic drums and fiber drums available
200kg–500kg: Blue tamper-proof HDPE drums or fiber drums, shipped with forklift pallets
500kg and above: Custom labels and customized packaging are acceptable as per your request
Carton boxes are also common packaging
Because of customs policy, sometimes commercial packaging is needed

2.3 Vardenafil powder delivery channel and lead time

Post office route: Around 5kg max, transit time about 15 days. Works well for Indonesia, Turkey, and South Africa. Slow transit, but customers don’t need to handle customs clearance themselves.
Express options: FedEx, UPS, DHL, 7 days around.
Air freight: We supply all customs clearance documents for you.
Truck/train transport: Suitable for Central Asian countries.
Sea freight: Only available for large bulk orders.
Our exclusive chemical shipping line: Door-to-door delivery available worldwide.

2.4 How to Use Vardenafil powder
2.4.1 Take 10mg per adult per time for erectile dysfunction. Most users shouldn’t take more than one dose within 24 hours.
2.4.2 The largest dose is 20mg per audlt per day, if have side effect start from 5mg.
2.4.3 Avanafil powder can treat primary pulmonary hypertension, it is an off-label use.
2.4.4 Avanafil powder could be used for benign prostatic hyperplasia (BPH), or combined erectile dysfunction and BPH treatment; it is an off-label use also.

2.5 Vardenafil powder available formulations are as follows:
Hard capsules
Film-coated tablets
immediate-release tablets
Hard capsules & tablets in plastic bottles
Hard capsules & tablets in single blister packs
Hard capsules & tablets in multi-blister packs
Oral dissolvable films
Oral suspensions
Oral syrup drinks
Dispersed tablets
Honey-based preparations
Coffee formulations
Medicated wine (can be mixed with whiskey)
Gummy candies (e.g., bear-shaped gummies)

2.6 Take-work time, lasting time compared to other PDE5 inhibitors
2.6.1 Vardenafil: takes effect in 15–30 mins, peak blood concentration at 1 hour, the lasting time is 4–6 hours, half-life is 4 hours
2.6.2 Sildenafil mesylate: takes effect in 30–60 mins, peak blood concentration at 1 hour, the lasting time is 4–6 hours, half-life is 4 hours
2.6.3 Avanafil powder: fastest acting, takes effect in around 15 mins, peak blood concentration in 30–45 mins, the lasting time is 6 hours, half-life is 6 hours
2.6.4 Tadalafil: takes effect in 30–45 mins, peak blood concentration at 2 hours, the lasting time is up to 36 hours, half-life is 18 hours

2.7 Vardenafi powder Side Effects & Usage Tips
2.7.1 Side effects
Very few side effects include flushing, headache, and nasal congestion; seldom classic blue vision similar to sildenafil citrate. No muscle soreness compared to tadalafil.
If these side effects occur, reduce the dose to 5mg
2.5.2 Drug interactions
Do not take together with nitrates (nitroglycerin, isosorbide mononitrate, etc.), as this may cause life-threatening low blood pressure.
2.7.3 Avoid grapefruit juice
Grapefruit juice slows vardenafil powder metabolism, raising blood drug levels and side effect risks.
2.7.4 Alcohol notes
Avoid excessive alcohol intake.
2.7.5 High-fat meals
High-fat meals have minimal impact on avanafil efficacy; they merely cause a slight delay in absorption, an advantage over sildenafil.

2.8 Solubility of Vardenafil powder in Various Solvents
2.8.1 Water
Vardenafil powder barely dissolves in plain water and easily turns cloudy. It only dissolves better in acidic water, and it’s much less soluble than avanafil.
2.8.2 Ethanol
It’s slightly soluble in ethanol. Very little dissolves at room temperature, and even heating only helps a bit, leaving a cloudy liquid.
2.8.3 Food-grade PEG400
It dissolves really well here to make clear solutions. This solvent is widely used for oral liquids and soft candies.
2.8.4 Propylene Glycol
This solvent dissolves vardenafil powder extremely well. It’s usually mixed with PEG400 to make stable high-dose liquid formulas.
2.8.5 Glycerin
It has moderate solubility in glycerin, not as good as PEG400 or propylene glycol. Glycerin works for syrups but can’t make high-concentration solutions alone.

2.9 Legal status of Vardenafi powder
The legal status of Vardenafi powder may vary by country. In many regions, it is classified as a prescription medication, while in others, it can be obtained over the counter. Always verify local regulations regarding the purchase and use of sildenafil mesylate to ensure compliance with the law.
We can supply GMP registration documents and customs clearance papers to support your marketing business.

3: Cooperation advantages about us 

We have focused on PDE5 inhibitors since 2011 and have solid expertise in this area. We are glad to develop exclusive customized products to support you and achieve win-win cooperation.
With over 10 years of experience, we have completed more than 120 clinical trials covering over 16,000 participants and provided reliable supply services to clients from more than 10 countries.

3.1 Factory Production Control Introduction 

Our modern factory meets cGMP, ISO22000, and FSSC22000 standards. All production lines are separated from sensitive chemicals and follow the latest 2026 GMP Class D cleanroom rules.
Our internal standards are stricter than USP43 and EP10. Every batch goes through three high-precision molecular sieve filters to remove unknown analogues and residues.
We use LC-MS/MS testing equipment to control genotoxic impurities and solvent residues like ethanol, methanol, and ethyl acetate. All test results stay below detection limits, providing pure and safe products for export and registration.

3.2 Lab and Quality Control System

We specialize in quality control for APIs and adopt a dual inspection system: in-house laboratory testing plus independent third-party testing.
Our in-house lab is fully equipped to conduct comprehensive tests, including HPLC, MS, GC, GC-MS, LCMS-ELSD, HPLC-ELSD, chirality tests, and nuclear magnetic resonance testing. Every batch undergoes full internal testing before shipment.
We also cooperate with three authoritative third-party labs, namely WuXi AppTec, Pony Testing, and Merieux. Objective and compliant test reports are provided to support clients’ global registration and sales.

3.3 Quality control of every batch(Below is an HPLC test report of tadalafil just for you referrence).

Every batch of products undergoes full HPLC quality testing, with stable and controllable test results. We can provide complete original test report images for you before you place an order, not COAs, since COAs can be modified. You can trace every step of our product quality.

3.4 We own a complete industrial chain covering intermediates, APIs, formula development, and finished products.
3.4.1 We work with tablet OEM clients. We can customize formulas and coating colors together.
3.4.2 Our mainstream hard capsules are size 00 and 0. We use high-speed automatic production machines.
3.4.3 We support custom blister molds and custom color boxes.
3.4.4 We have professional dissolution technology. It fits coffee oral liquid, honey oral liquid, and oral wine.
3.4.5 We make gummies in custom shapes, like bear gummies.
3.4.6 Custom oral dissolvable films (oral strips) can be made to order.
3.4.7 We provide bottle packaging. Customers can get personalized colorful labels.
3.4.8 We have many compound formulas for choice.
We do not suggest mixing PDE5 active ingredients.
We do not suggest mixing PDE5 active ingredients like sildenafil citrate, Sildenafil Mesylate, avanafil, water-soluble tadalafil, alcohol-soluble tadalafil, tadalafil derivative, undetected tadalafil analogs like Jinyangjian, Xinyangjian, 520, SX, and vardenafil HCl. But it is good combined with herbal PDE5 inhibitors like epimedium extract, Ginseng extract, and Kaempferia parviflora.
The best match is tadalafil plus dapoxetine. Formulas added with plant extracts also perform well, vardenafil powder not can mixing with dapoxetine.

3.5 We are well-versed in relevant laws, regulations, and customs policies worldwide.
We specialize in the men’s PDE5 inhibitor area, and we are familiar with local regulations and patents.
The clients should follow their local laws. Based on clients’ demands and local policies, we can develop derivative products and undetectable PDE5 inhibitors.
We also provide product registration services for our clients.

4: In our opinion, PDE5 inhibitors belong to a niche market. Their patents are expiring one after another, yet these pharmaceutical products must still be sold in compliance with local laws and regulations. We are looking for professional partners in this field. If you don’t have relevant experience yet, partnering with us will make you an expert in this industry.

References

1: Verified tadalafil vendor in Chemicalbook from:
https://www.chemicalbook.com/manufacturer/shaanxi-linkyou-biotechnology-25552/
2: A professional PDE5 finished products producer
https://www.linkyougroup.com
3: Title: Ocular side effects of Levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects
Source: Dove Medical Press (Open Access)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6305137/
4: Title: BAYER PHARMA AG v. WATSON LABORATORIES, INC. (Vardenafil ODT Formulation Patent)
Source: U.S. Court of Appeals for the Federal Circuit
Link: https://www.cafc.uscourts.gov/opinions-orders/16-2169.opinion.10-30-2017.1.pdf
5: Title: REVITALISE: A Large Observational Study Assessing the Safety and Effectiveness of Vardenafil in Men With Erectile Dysfunction and Metabolic Syndrome
Source: PMC (PubMed Central Open Access)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC5005302/
6: Title: MEDICAMENTS CONTAINING VARDENAFIL HYDROCHLORIDE TRIHYDRATE AND PROCESSES FOR THE MANUFACTURE THEREOF
Source: European Patent Office (EPO Open Patent)
Link: https://data.epo.org
7: Title: COADMINISTERED VARDENAFIL (FOR ERECTILE DYSFUNCTION) AND TAMSULOSIN DO NOT INDUCE HYPOTENSION IN PATIENTS WITH BENIGN PROSTATIC HYPERTROPHY
Source: Oxford Academic Full PDF
Link: https://academic.oup.com/ajh/article-pdf/17/S1/16A/394328/17_S1_16Ac.pdf