Dapoxetine powder

Dapoxetine powder CAS119356-77-3 GMP factory supply
1: What Is Dapoxetine Powder & Specifications and Core Pharmaceutical Applications

1.1 What is Dapoxetine Powder API

Dapoxetine powder is an SSRI inhibitor (Selective Serotonin Reuptake Inhibitors); it can be combined with PDE5 inhibitors like sildenafil citrate, sildenafil mesylate, tadalafil powder, water-soluble tadalafil, alcohol-soluble tadalafil, tadalafil derivatives, undetected tadalafil analogs like Jinyangjian, Xinyangjian, Huanyangjian, 520, SX. It can be combined with plant PDE inhibitors like epimedium extract, Ginseng extract, and Kaempferia parviflora. It is not suggested to combine with avanafil powder, because avanafil powder take works in 10-15 minutes, but dapoxetine HCL take works in 60-90 minutes.

1.2 Dapoxetine Powder API Chemical Specifications & CAS Number
1.2 .1 API name: Dapoxetine Powder
1.2 .2 Appearance: White crystal powder, sometimes light pink white crystal powder
1.2 .3 Taste: Compared with sildenafil citrate, avanafil, tadalafil, and vardenafil. The dapoxetine powder has the strongest bitter and spicy taste.
1.2 .4 Specification: 98%-102% powder according to USP, EP
1.2 .5 CAS No.:119356-77-3
1.2 .6 Molecular Formula: C21H23NO
1.2 .7 Molecular Weight: 305.41
1.2 .8 Certificates: GMP, cGMP, CEP, CDE, FDA, Organic, Kosher, ISO, HALAL, FSSC, DMF
1.2 .9 Testing partner of independent lab: Wuxi AppTec, Merieux
1.2 .10 Test Method: HPLC, UV-visible spectrophotometry
1.2 .11 Storage method:15～25℃, RH＜60%, store away from light
1.2 .12 Export only, welcome research labs and professionals

1.3 Pharmaceutical Applications (5 Benefits of dapoxetine powder for Health).
1.3.1. Effectively last longer and fix premature ejaculation
1.3.2. Ease nervousness and low self-esteem in bed
1.3.3. Improve relationship with your partner, reduce conflicts
1.3.4. Works fast and leaves the body quickly, no buildup
1.3.5. Won’t affect erection, can be taken with PDE5 inhibitors

2: FAQ about dapoxetine powder

2.1 Dapoxetine powder Order Quantity
10g: Free samples for your lab test and even body test
1kg: Trial order to test our secure door-to-door delivery service
25kg–200kg: Ideal for you to check our stable product supply; new batches are in stock
200kg–500kg: We will reship free of charge if goods get lost. We are your reliable partner
500kg and above: Each batch comes with an HPLC test report. We can meet your specific requirements on impurities and particle size, and we’ll be your ideal finished product partner.

2.2 Dapoxetine powder packaging 

10g: Packed in aluminum foil bags with inner transparent PE bags to prevent leakage
1kg: Packed in aluminum foil bags with inner transparent PE bags to prevent leakage
25kg–200kg: Blue tamper-proof HDPE plastic drums and fiber drums available
200kg–500kg: Blue tamper-proof HDPE drums or fiber drums, shipped with forklift pallets
500kg and above: Custom labels and customized packaging are acceptable as per your request
Carton boxes are also common packaging
Because of customs policy, sometimes commercial packaging is needed

2.3 Dapoxetine powder delivery channel and lead time

Post office route: Around 5kg max, transit time about 15 days. Works well for Indonesia, Turkey, and South Africa. Slow transit, but customers don’t need to handle customs clearance themselves.
Express options: FedEx, UPS, DHL, 7 days around.
Air freight: We supply all customs clearance documents for you.
Truck/train transport: Suitable for Central Asian countries.
Sea freight: Only available for large bulk orders.
Our exclusive chemical shipping line: Door-to-door delivery available worldwide.

2.4 How to Use Dapoxetine powder
2.4.1 Take 10mg per adult per time for premature ejaculation. Most users shouldn’t take more than one dose within 24 hours.
2.4.2 The largest dose is 60mg per adult per day; if you have side effects, start from 30mg.
2.4.3 Dapoxetine powder can be combined with PDE5 inhibitors treatment for erectile dysfunction

2.5 Dapoxetine powder available formulations are as follows:
Hard capsules
Film-coated tablets
immediate-release tablets
Hard capsules & tablets in plastic bottles
Hard capsules & tablets in single blister packs
Hard capsules & tablets in multi-blister packs
Oral dissolvable films
Oral suspensions
Oral syrup drinks
Dispersed tablets
Honey-based preparations
Coffee formulations
Medicated wine (can be mixed with whiskey)
Gummy candies (e.g., bear-shaped gummies)

2.6 Dapoxetine powder can be combined with PDE5 inhibitors as below
2.6.1 Sildenafil mesylate: takes effect in 30–60 mins, peak blood concentration at 1 hour, the lasting time is 4–6 hours, half-life is 4 hours
2.6.2 Tadalafil: takes effect in 30–45 mins, peak blood concentration at 2 hours, the lasting time is up to 36 hours, half-life is 18 hours
2.6.3 Vardenafil: takes effect in 15–30 mins, peak blood concentration at 1 hour, the lasting time is 4–6 hours, half-life is 4 hours
2.6.4 Plant PDE inhibitors like epimedium extract, Ginseng extract, and Kaempferia parviflora.
PS: Avanafil powder: fastest acting, takes effect in around 15 mins, peak blood concentration in 30–45 mins; it is NOT suitable for combination.

2.7 Dapoxetine powder Side Effects & Usage Tips
2.7.1 Side effects
The side effects include Nausea, dizziness, headache, drowsiness, and fatigue. If these side effects occur, reduce the dose to 30mg. Best taken on an empty stomach; take with a full glass of water to reduce dizziness and nausea.
2.5.2 Not suitable for only difficulty getting erections, normal ejaculation duration
2.7.3 Not suitable for severe liver disease, severe heart disease, low blood pressure
2.7.4 Not suitable for taking antidepressants or psychiatric drugs and have not stopped them for 7 full days
2.7.5 Not suitable for people with frequent social drinking who cannot cut out alcohol
2.7.6 High-fat meals have minimal impact on avanafil efficacy; they merely cause a slight delay in absorption, best taken on an empty stomach
2.7.7 Insufficient safety data for patients over 65 years old; use is not recommended

2.8 Solubility of Dapoxetine powder in Various Solvents
2.8.1 Water
Dapoxetine powder almost insoluble in water.
2.8.2 Ethanol
It dissolves well in ethanol (alcohol drinks) and makes a clear liquid at room temperature.
But never take it with alcohol — alcohol worsens dizziness, nausea, and low blood pressure, and may cause fainting.
2.8.3 Food-grade PEG400
It dissolves really well in food-grade PEG400, forming a clear liquid at room temperature. This solvent is widely used for oral liquids and soft candies, and is often mixed with propylene glycol to make stable high-concentration formulas.
2.8.4 Propylene Glycol
It has high solubility in propylene glycol, better than PEG400. It can make high-concentration clear liquid, and is often mixed with PEG400 for stable formulas with no sediment.
2.8.5 Glycerin
It has moderate solubility in glycerin, not as good as propylene glycol or PEG400. It fits syrup products and cannot make high-concentration liquid alone.

2.9 Legal status of Dapoxetine powder
The legal status of Dapoxetine powder may vary by country. In many regions, it is classified as a prescription medication, while in others, it can be obtained over the counter. Always verify local regulations regarding the purchase and use of sildenafil mesylate to ensure compliance with the law.
We can supply GMP registration documents and customs clearance papers to support your marketing business.

3: Cooperation advantages about us 

We have focused on PDE5 inhibitors since 2011 and have solid expertise in this area. We are glad to develop exclusive customized products to support you and achieve win-win cooperation.
With over 10 years of experience, we have completed more than 120 clinical trials covering over 16,000 participants and provided reliable supply services to clients from more than 10 countries.

3.1 Factory Production Control Introduction

Our modern factory meets cGMP, ISO22000, and FSSC22000 standards. All production lines are separated from sensitive chemicals and follow the latest 2026 GMP Class D cleanroom rules.
Our internal standards are stricter than USP43 and EP10. Every batch goes through three high-precision molecular sieve filters to remove unknown analogues and residues.
We use LC-MS/MS testing equipment to control genotoxic impurities and solvent residues like ethanol, methanol, and ethyl acetate. All test results stay below detection limits, providing pure and safe products for export and registration.

3.2 Lab and Quality Control System

We specialize in quality control for APIs and adopt a dual inspection system: in-house laboratory testing plus independent third-party testing.
Our in-house lab is fully equipped to conduct comprehensive tests, including HPLC, MS, GC, GC-MS, LCMS-ELSD, HPLC-ELSD, chirality tests, and nuclear magnetic resonance testing. Every batch undergoes full internal testing before shipment.
We also cooperate with three authoritative third-party labs, namely WuXi AppTec, Pony Testing, and Merieux. Objective and compliant test reports are provided to support clients’ global registration and sales.

3.3 Quality control of every batch(Below is an HPLC test report of tadalafil just for you referrence).

Every batch of products undergoes full HPLC quality testing, with stable and controllable test results. We can provide complete original test report images for you before you place an order, not COAs, since COAs can be modified. You can trace every step of our product quality.

3.4 We own a complete industrial chain covering intermediates, APIs, formula development, and finished products.
3.4.1 We work with tablet OEM clients. We can customize formulas and coating colors together.
3.4.2 Our mainstream hard capsules are size 00 and 0. We use high-speed automatic production machines.
3.4.3 We support custom blister molds and custom color boxes.
3.4.4 We have professional dissolution technology. It fits coffee oral liquid, honey oral liquid, and oral wine.
3.4.5 We make gummies in custom shapes, like bear gummies.
3.4.6 Custom oral dissolvable films (oral strips) can be made to order.
3.4.7 We provide bottle packaging. Customers can get personalized colorful labels.
3.4.8 We have many compound formulas for choice.
We suggest dapoxetine powder combined with PDE5 inhibitors, except avanafil; other PDE5 inhibiting active ingredients like sildenafil citrate, Sildenafil Mesylate, avanafil, water-soluble tadalafil, alcohol-soluble tadalafil, tadalafil derivative, undetected tadalafil analogs like Jinyangjian, Xinyangjian, 520, SX, and vardenafil HCl. It is also good combined with herbal PDE5 inhibitors like epimedium extract, Ginseng extract, and Kaempferia parviflora.

3.5 We are well-versed in relevant laws, regulations, and customs policies worldwide.
We specialize in the men’s PDE5 inhibitor area and dapoxetine powder, and we are familiar with local regulations and patents.
The clients should follow their local laws. Based on clients’ demands and local policies, we can develop derivative products and undetectable PDE5 inhibitors. PDE5 inhibitors combined with dapoxetine. We also provide product registration services for our clients.

4: In our opinion, dapoxetine powder belongs to a niche market similar to PDE5 inhibitors. Their patents are expiring one after another, yet these pharmaceutical products must still be sold in compliance with local laws and regulations. We are looking for professional partners in this field. If you don’t have relevant experience yet, partnering with us will make you an expert in this industry.

References

1: Verified tadalafil vendor in Chemicalbook from:
https://www.chemicalbook.com/manufacturer/shaanxi-linkyou-biotechnology-25552/
2: A professional PDE5 finished products producer
https://www.linkyougroup.com
3: Title: Safety and Effectiveness of Dapoxetine On Demand in Chinese Men With Premature Ejaculation: Results of a Multicenter, Prospective, Open-Label Phase IV Study
Source: Oxford Academic Open Access
Link: https://academic.oup.com/smoa/article-pdf/9/2/100296/48796742/smoa_9_2_100296.pdf
4: Title: Cardiovascular safety profile of dapoxetine during the premarketing evaluation
Source: PubMed Central
Link: https://pubmed.ncbi.nlm.nih.gov/21410293/
5: Title: PHARMACEUTICAL COMPOSITIONS OF PDE-5 INHIBITORS AND DAPOXETINE
Source: European Patent Office (EPO Open Patent PDF)
Link: https://data.epo.org/publication-server/rest/v1.0/publication-dates/20191211/patents/EP2490676NWB1/document.pdf
6: Title: Pharmacokinetics and Safety of Dapoxetine Hydrochloride in Healthy Chinese Men: Impact of Dose and High-Fat Meal
Source: Sci-Hub Full Text PDF
Link: https://www.sci-hub.ru/download/2024/8522/30d40f56d6e6ac7e4858e3903cb6d1c5/liu2021.pdf
7: Title: Oral Film Formulations Comprising Dapoxetine and Tadalafil (EP2698147)
Source: European Patent Office
Link: https://data.epo.org/publication-server/rest/v1.2/patents/EP2698147NWB1/document.html