3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%

3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% from GMP factory

1: What Is 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% & Specifications and Core Pharmaceutical Applications

1.1 What is 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%

3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% is taken from the leaves of Epimedium. They have long been used as a nourishing tonic in Chinese Traditional Medicine. Modern research also shows they act as natural PDE inhibitors. Compared to chemical PDE5 inhibitors like sildenafil citrate, sildenafil mesylate, tadalafil, avanafil, vardenafil HCl, 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% has no side effects; it is suitable for long-term consumption and brings health benefits. Other plant PDE inhibitors include Ginsenosides HPLC 45% and Kaempferia parviflora extract.
PDE5 inhibitors like 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% could be combined with dapoxetine; dapoxetine does not belong to PDE inhibitors; dapoxetine is the only oral medicine for premature ejaculation; it belongs to the class of SSRI inhibitors(Selective Serotonin Reuptake Inhibitors).

1.2  3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%
1.2.1 Commercial name: Epimedium Extract Powder
1.2 .2 Botanical source: Epimedium brevicornu Maxim.
1.2 .3 Used Part: Leaves
1.2 .4 Extract Solvent: Semi-synthetic artificial derivatives
1.2 .5 CAS no.:1067198-74-6
1.2 .6 Molecular Formula: C25H28O8. Molecular Weight: 456.49
1.2 .7 3,7-Bis(2-hydroxyethyl) Icaritin HPLC testing: HPLC 98%
1.2 .8 Appearance: Yellow fine powder Odor & taste
1.2 .9 Odor & taste: Bitter and characteristic flavor
1.2 .10 Particle size: 95% pass 80 mesh according to CP2020
1.2 .11 Testing partner of independent lab: Wuxi AppTec, Merieux
1.2 .12 Test Method: HPLC
1.2 .13 Storage method:15～25℃, RH＜60%, store away from light

1.3 Pharmaceutical Applications: 7 Benefits of 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%
1.3.1 Improve men’s health
1.3.2 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% is natural PDE5 inhibitors. They relax local blood vessels to boost blood flow, with no side effects.
1.3.3 Good for your heart and blood vessels
1.3.4 Taking it regularly long-term keeps your cardiovascular system healthy.
1.3.5 Chase away exhaustion and lift your energy levels
1.3.6 Relieve prostate discomfort and keep your urinary system healthy
1.3.7 Calm your mind for sound sleep, ease insomnia brought on by poor physical health
Quick tip: 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% works gently. You have to take them consistently over time to see steady improvements.

2: FAQ about 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%

2.1 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% order quantity
1-5g: sample for lab test, even body test
10g-1kg: Trial order to test our secure door-to-door delivery service
1kg +: Ideal for you to check our stable product supply; new batches are in stock

2.2 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% packaging 

10g-1kg: Trial order to test our secure door-to-door delivery service
1kg +: Aluminum can
Carton boxes are also common packaging
Because of customs policy, sometimes commercial packaging is needed

2.3 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% delivery channel and lead time

Post office route: Around 5kg max, transit time about 15 days. Works well for Indonesia, Turkey, and South Africa. Slow transit, but customers don’t need to handle customs clearance themselves.
Express options: FedEx, UPS, DHL, 7 days around.
Air freight: We supply all customs clearance documents for you.
Truck/train transport: Suitable for Central Asian countries.
Sea freight: Only available for large bulk orders.
Our exclusive chemical shipping line: Door-to-door delivery available worldwide.
The best way is formal customs clearance for import

2.4 How to use 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%
2.4.1 Long-term daily use
Take 3-8mg 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% per day
2.4.2 Basic daily use for a 3-week treatment course
Take 10- 20 mg of 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% per day. You can take it all at once or split it into morning and evening doses with warm water.
2.4.3 For temporary use as PDE5 inhibitors like sildenafil citrate, tadalafil, avanafil, vardenafil, etc.
Take 15- 25 mg at a time, 60-90 minutes before
2.4.4 For pulmonary hypertension and chronic inflammation care
Daily total dose: 20 to 40 mg, take half in the morning and half at night
Check your blood pressure and heart rate regularly

2.5 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% available formulations are as follows:
Hard capsules
Film-coated tablets
Hard capsules & tablets in plastic bottles
Hard capsules & tablets in single blister packs
Hard capsules & tablets in multi-blister packs
Oral dissolvable films (fast-dissolving oral films)
Oral suspensions
Oral syrup drinks
Honey-based preparations
Coffee formulations
Medicated wine (can be mixed with whiskey)
Gummy candies (e.g., bear-shaped gummies)

2.6 Take-work time, lasting time compared to other chemical PDE5 inhibitors
2.6.1 Sildenafil mesylate: takes effect in 30–60 mins, peak blood concentration at 1 hour, the lasting time is 4–6 hours, half-life is 4 hours
2.6.2 Vardenafil: takes effect in 15–30 mins, peak blood concentration at 1 hour, the lasting time is 4–6 hours, half-life is 4 hours
2.6.3 Avanafil: fastest acting, takes effect in around 15 mins, peak blood concentration in 30–45 mins, the lasting time is 6 hours, half-life is 6 hours
2.6.4 Tadalafil: takes effect in 30–45 mins, peak blood concentration at 2 hours, the lasting time is up to 36 hours, half-life is 18 hours
PS: 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% take works 60-90 minutes; it suit for long-term use

2.7 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% Usage Tips
2.7.1 Don’t take it together with strong tea, coffee, or radishes — these will stop your body from absorbing 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% well.
2.7.2 Best time to take it: after breakfast and dinner. Avoid taking it on an empty stomach to prevent stomach discomfort.
2.7.3 If you easily get overheated (dry mouth, acne, constipation), take a smaller dose and skip days occasionally.
2.7.4 This is only a nutritional supplement for daily care. It cannot replace prescription medicine to treat illnesses.

2.8 Solubility of 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%
2.8.1 In water, 2mg per mL in warm water
2.8.2 In alcohol, about 1 gram can dissolve in every 100 mL of 50-degree alcohol, much better than other epimedium extracts like icariin.

2.9 Legal status of 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%
2.9.1 If sold as food in Muslim-majority countries, the product needs both HALAL and KOSHER certifications.
2.9.2 If used in cosmetics, it has to meet local cosmetic qualification standards.
2.9.3 If sold as medicine, it must follow local laws and pharmacopoeia requirements.

3: Cooperation advantage about us 

We have focused on PDE5 inhibitors since 2011 and have solid expertise in this area. We are glad to develop exclusive customized products to support you and achieve win-win cooperation.
With over 10 years of experience, we have completed more than 120 clinical trials covering over 16,000 participants and provided reliable supply services to clients from more than 10 countries.

3.1 Factory Production Control Introduction
Our modern factory meets cGMP, ISO22000, and FSSC22000 standards. All production lines are separated from sensitive chemicals and follow the latest 2026 GMP Class D cleanroom rules.
Our internal standards are stricter than USP43 and EP10. Every batch goes through three high-precision molecular sieve filters to remove unknown analogues and residues.
We use LC-MS/MS testing equipment to control genotoxic impurities and solvent residues like ethanol, methanol, and ethyl acetate. All test results stay below detection limits, providing pure and safe products for export and registration.

3.2 Lab and Quality Control System
We specialize in quality control for APIs and adopt a dual inspection system: in-house laboratory testing plus independent third-party testing.
Our in-house lab is fully equipped to conduct comprehensive tests, including HPLC, MS, GC, GC-MS, LCMS-ELSD, HPLC-ELSD, chirality tests, and nuclear magnetic resonance testing. Every batch undergoes full internal testing before shipment.
We also cooperate with three authoritative third-party labs, namely WuXi AppTec, Pony Testing, and Merieux. Objective and compliant test reports are provided to support clients’ global registration and sales.

3.3 Quality control of every batch: below is 3,7-Bis(2-hydroxyethyl) Icaritin HPLC98% lab test
Every batch of products undergoes full HPLC quality testing, with stable and controllable test results. We can provide complete original test report images for you before you place an order, not COAs, since COAs can be modified. You can trace every step of our product quality.

3.4 We own a complete industrial chain covering intermediates, APIs, formula development, and finished products.
3.4.1 We work with tablet OEM clients. We can customize formulas and coating colors together.
3.4.2 Our mainstream hard capsules are size 00 and 0. We use high-speed automatic production machines.
3.4.3 We support custom blister molds and custom color boxes.
3.4.4 We have professional dissolution technology. It fits coffee oral liquid, honey oral liquid, and oral wine.
3.4.5 We make gummies in custom shapes, like bear gummies.
3.4.6 Custom oral dissolvable films (oral strips) can be made to order.
3.4.7 We provide bottle packaging. Customers can get personalized colorful labels.
3.4.8 We have many compound formulas for choice.
We do not suggest mixing PDE5 active ingredients especial tadalafil derivatives.
We also do not suggest mixing PDE5 active ingredients like sildenafil citrate, Sildenafil Mesylate, tadalafil, avanafil, water-soluble tadalafil, alcohol-soluble tadalafil, tadalafil derivatives, undetected tadalafil analogs like Jinyangjian, Xinyangjian, 520, SX, and vardenafil HCl. But it is good combined with herbal PDE5 inhibitors like epimedium extract, ginsenosides HPLC45%, and Kaempferia parviflora.
The best match is 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98% plus dapoxetine. Formulas added with tadalafil also perform well.

3.5 We are well-versed in relevant laws, regulations, and customs policies worldwide.
We specialize in the men’s PDE5 inhibitor area, and we are familiar with local regulations and patents.
The clients should follow their local laws. Based on clients’ demands and local policies, we can develop derivative products and undetectable PDE5 inhibitors.
We also provide product registration services for our clients.

4: In our opinion, PDE5 inhibitors belong to a niche market, especial the plant PDE5 inhibitors like 3,7-Bis(2-hydroxyethyl) Icaritin HPLC 98%. For the chemical inhibitors, their patents are expiring one after another, yet these pharmaceutical products must still be sold in compliance with local laws and regulations. We are looking for professional partners in this field. If you don’t have relevant experience yet, partnering with us will make you an expert in this industry.

References

1: Verified tadalafil vendor in Chemicalbook from:
https://www.chemicalbook.com/manufacturer/shaanxi-linkyou-biotechnology-25552/
2: A professional PDE5 finished products producer
https://www.linkyougroup.com
3: Title: Aphrodisiac Principles and other Constituents from the Roots of Panax quinguefolium and Panax ginseng
Source: PMC (PubMed Central, open full text)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC11292828/
4: Title: Structural-Activity Relationship of Ginsenosides from Steamed Ginseng in the Treatment of Erectile Dysfunction
Source: PubMed
Link: https://pubmed.ncbi.nlm.nih.gov/29298510/
5: Title: Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
Source: PLOS ONE / PMC
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6754136/
6: Title: Botanical drugs for treating erectile dysfunction: clinical evidence
Source: Frontiers in Pharmacology (open access)
Link: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1232774/full
7: Title: Icaritin (ICT) derivative and preparation method and application thereof
Source: Patsnap
Link: https://eureka.patsnap.com/patent-CN110357845A